Implementing an intensive lifestyle intervention (ILI) aimed at weight loss can attenuate the risk of obesity-related cancers in adults who are overweight, obesity, or have type 2 diabetes, according to the findings of a study published in Obesity.
In this study, researchers evaluated 4,859 participants who had not reported a cancer diagnosis at baseline (except for nonmelanoma cancer). The population of interest were required to meet the following criteria: 45 to 76 years of age, body mass index greater than 25, glycated hemoglobin less than 11 percent, blood pressure readings less than 160/100 mm Hg, triglyceride levels less than 600 mg/dL and completion of a maximal graded exercise test. The researchers arbitrarily assigned to an ILI or a DSE by a web-based data management system between August 22, 2001 and April 30, 2004.
According to the results, following an average follow-up of 11 years, 684 participants (332 in ILI and 352 in DSE) were diagnosed with cancer. The researchers observed an incidence rate of obesity-related cancers were 6.1 and 7.3 per 1,000 person-years in ILI and DSE, respectively, with a hazard ratio (HR) of 0.84 (95 CI, 0.68 to 1.04).